I have a few MX Masters (a 2S and a 3) and for some reason they really bother my hand/wrist after a few hours of use. Not sure if it's the weight, or the angle it forces my hand into. I love the clicks and the scroll wheel on them, though. I find that the Logitech G502 or Razer Basilisk V3 work a lot better for my hand without making it hurt after a while. Logitech does make great products though. I used a G400s for 7 years and it still works great, I just wanted something different. Also used a G602 at work for a few years before wanting something with an infinite scroll wheel. I'm also pretty hard on my mice as my work requires a lot of clicking, scrolling, etc.