Consider if every home was heated with a co2 unit. In that case there would be a lot of potential leaks but since it's co2 it's not that big of a concern. The units wouldn't be as efficient but if all our electricity was produced with renewables it wouldn't really matter.

If every unit was R-32 than yes it might be more efficient but leaks could cause some damage to the climate.

Tough to say for sure which one would be better for the enviroment but I think end goal currently should be co2 heat pumps and solar panels on every well insulated house. Don't think we have a better set up enviroment wise right now than that.