Submitted by tonymmorley t3_yr6epv in Futurology
Comments
DoorFacethe3rd t1_ivu915v wrote
Glad you are on the mend, that sounds horrifying.
tonymmorley OP t1_ivs85w5 wrote
It might feel at first glance like this is superficial news; (pharmaceutical companies doing capitalist pharmaceutical things), but it's a big deal. Every new and promising antibiotic candidate is a big deal worth celebrating. š
>New antibiotic passes through the first phase of clinical trials with ease
The last truly novel antibiotic compounds that made it to the market were discovered in the 1980s, leaving a void of innovation that has lasted decades, with many experts worried about the very real possibility of an āantibiotic apocalypseā. ā¬ ļø Watch this:
>"The drug, called QPX9003, is a promising candidate for tackling Gram-negative bacteria which cause serious infections like pneumonia, urinary tract infections, peritonitis and meningitis." "Gram-negative āsuperbugsā are becoming increasingly hard to treat, as they develop resistance to most common antibiotics."
Hey team, I'm a progress studies researcher and progress proponent; if you enjoy my content, you're welcome to follow the majority of my work on the blue bird platform (before Elon tanks the platform)
tonymmorley OP t1_ivs8tzc wrote
Interesting side note: [As a young, healthy, and active cyclist] In January I woke up with a mystery infection in my elbow, (doctors still don't know what caused it, possibly a "micro-cut" that let in a one in a million bacteria); and I went from active outdoors person to being admitted to the ICU in septic shock within 12 hours, and spent two weeks in hospital undergoing two surgeries. Antibiotics, saved my life, just this year.
Hammakprow t1_ivsjd3t wrote
Likewise, I was in ICU about a year ago with sepsis. It took 9 different antibiotics to save my life.
Spathers t1_ivv0qdf wrote
Similar experience here. Salmonella infection that turned into sepsis. Was taken to the hospital with high fever, severe dehydration, and 0% kidney function. ICU for 3 days, hospitalized for a total of a week.
The hospital staff said I was about an hour away from dying if I hadnāt received medical intervention. I was given several antibiotics via IV, which saved my life. And Iām extremely lucky to have my kidney function back.
Iām still not sure how I got itā¦
LegitPancak3 t1_ivu6sr0 wrote
As someone taking multiple classes of microbiology, do you mind sharing what the bacteria was? Iām certainly curious :)
TehOwn t1_ivse2sb wrote
What's to stop the bacteria from developing resistance to this new antibiotic?
tonymmorley OP t1_ivsebqi wrote
Nothing, the war never ends. It's a litral arms race, but failure to continue winning would kill hundreds of millions. Check out the video "watch this" linked in the pinned comment.
TehOwn t1_ivseqtx wrote
I'll definitely watch it later. I may have seen it already, I love some Kurzgesagt, but I'll refresh my memory. Thanks!
Edit: Thanks for the award! I wish I could reciprocate!
polar_pilot t1_ivsgh68 wrote
Hypothetically, say we keep developing new antibiotics. Could a bacteria evolve resistance to all of them? Or would resisting one antibiotic make them vulnerable to a different one?
tonymmorley OP t1_ivsgqge wrote
Unlikely and maybe. Antibodies are like keys not bombs, they kill in very a specific and targeted manner. It would be difficult but not impossible to evolve blanket immunity. But some bacteria are multi-resistant. Check out the "watch this" link for more information.
[deleted] t1_ivsq5lz wrote
Would they be able to develop resistance to phages as well, or is that the actual holy grail of antibacterial treatment it's made out to be?
grapescottingson t1_ivt02s2 wrote
Phages have the benefit of co-evolving with their prey so I would hope that they would be a more resilient treatment strategy.
banana_pirate t1_iw4on3c wrote
Fun thing is that developing resistance against viruses and chemicals are some what opposed to each other.
As such you notice that bacteria resistant to antibiotics become more vulnerable to antibiotics as they become more resistant to viruses.
It likely has to do with antibiotic resistance often using a mechanism that pumps the drug out of the cell, whereas virus resistance requires not presenting proteins on their surface. The pumps are proteins, so you can't have both.
LegitPancak3 t1_ivu7uye wrote
The thing is developing resistance to an antibiotic often forces the bacteria to give up something that is typically important to it, such as survival in certain environments or factors that make it more immunogenic. Not long after an antibiotic is taken off the common administration protocols, the bugs want those factors back ASAP, and will readily revert the mutation. So smart administration and rotation of antibiotics could ensure that we always have effective treatments.
gregorydgraham t1_ivsltcm wrote
Nothing but each antibiotic resistance has a cost to the bacteria, so hopefully eventually weāll have enough different antibiotics that no bacteria can afford to be resistant to all of them
Taeryr t1_ivseg0n wrote
Proper antibiotic prescriptions and following through with courses to completion. We are more strict than we used to be which helps but eventually there will be new resistance. It also adds one more to a long line to deal with other resistant strains, as most are resistant to some but not all antibiotics.
propargyl t1_ivsykig wrote
https://www.nature.com/articles/s41467-022-29234-3
'A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens.' This drug was designed and tested to demonstrate it is effective against multidrug resistant pathogens.
yodelingllama t1_ivsna18 wrote
This is great news, I have family who's been in the hospital for over 3 months now for an abscess caused by infection from an unknown source and they've been through 6 antibiotics. As a pharmacist myself I'm well aware that the antibiotic pipeline is running dry fast. Hopefully by the time this enters the market other people will be able to benefit from it.
Chr1s78987x t1_iw98lst wrote
I'd argue it's not too noteworthy because over 7 in 10 drugs make it to phase 2 trials. This is media hype pumped from whatever company developed this
hawkwings t1_ivskjpn wrote
Now, we need to keep this drug away from farmers. If farmers start using it, bacteria will become immune.
CalvinSays t1_ivtpd54 wrote
Why are farmers the problem?
saffron_boy t1_ivtrk1d wrote
They give antibiotics to their animals on a daily basis based on an old myth that itās good to keep them healthy.
Swagastan t1_ivtym7u wrote
It actually is used as a growth promoter, chickens grow quicker when given antibiotics.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC153145/
āShortly after the introduction of the therapeutic use of antibiotics, the growth-promoting effect of these products in chickens was discovered by feeding fermentation offal from the chlortetracycline production of Streptomyces aureofaciens (122). Several antibiotics have been in use as growth promoters of farm animals ever since. The introduction of these agents coincided with intensive animal rearing. These products improved feed conversion and animal growth and reduced morbidity and mortality due to clinical and subclinical diseases. The average growth improvement was estimated to be between 4 and 8%, and feed utilization was improved by 2 to 5% (90).ā
CalvinSays t1_ivtsop1 wrote
Where did you get this information? I'm a fifth generation agriculturalist and I promise we don't give animals antibiotics everyday. That is way too expensive.
saffron_boy t1_ivu5og8 wrote
CalvinSays t1_ivu6c2t wrote
I fail to see where any one of those sources said agriculturalists give antibiotics to their animals everyday. But don't listen to me. My family is only raises livestock for a living.
imafraidofmuricans t1_ivu9kqj wrote
It was (is) a big enough issue that the practice of putting antibiotics in livestock feed was outlawed in Sweden in the 80s.
Your anecdote is noted.
Let's put it this way: what is more likely?
Nobody is putting antibiotics on feed and it was outlawed just because, and all these scientists studying the spread of antibiotic resistant bacteria from livestock to humans are just doing it for absolutely no reason (again, see the links above, that's what they are about).
Or
Your family's farm is not typical.
CalvinSays t1_ivuaq09 wrote
The objection was not that antibiotics are used in animal agriculture (to treat infections). The objection was that we supposedly give it to animals every day.
Animals deserve medical care too. Doctors over prescribed antibiotics which is a huge issue for antibiotic resistance but agriculturalists are always the scapegoat.
DebrecenMolnar t1_ivufneb wrote
Nobody here is arguing against the use of antibiotics for illness.
What are you failing to understand is that the argument is about the fact that livestock typically are given antibiotics for the sole fact that it will make them grow faster.
It has nothing to do with disease-related administration of antibiotics.
If youāre hung up on the āevery dayā part just forget about that. It was not accurate. But it would be accurate to say that many livestock are given antibiotics for growth rather than for illness, which is a huge problem.
Congrats on not doing that on your farm. Take your āfarm animals deserve healthcare tooā shit elsewhere; nobody here is suggesting otherwise. In fact, quite the opposite.
mr_bedbugs t1_ivuwrur wrote
>farm animals deserve healthcare too
We don't even have healthcare for our own citizens.
YaAbsolyutnoNikto t1_iw172ci wrote
Speak for yourself. I do in my country. I'm also currently living in a developing country in Asia and I still have it.
saffron_boy t1_ivuc4n5 wrote
āDaily basisā was an exaggeration, my bad. Itās difficult to carry tone over message.
The issue is giving animals antibiotics as a preventive measure rather than a treatment of infection. Itās a practice that a lot of farmers still follow.
ThePickleConnoisseur t1_ivubxxf wrote
They give them to animals. I believe a few years back Chinese farms fed them a cheap antibiotic which was considered the last line of defense and made a new strain of resistant bacteria
Chr1s78987x t1_iw98q3q wrote
The urban elitism runs deep with you I suppose
makvalley t1_ivsry4m wrote
Wonder what the tinfoil hat crowd will say about this one
IdeaJailbreak t1_ivtgu0w wrote
Made from infants, something about a shadowy world order, and finally some sort of religious belief that only applies in this one case but not when taking aspirin
[deleted] t1_ivth0ai wrote
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mr_bedbugs t1_ivuxg8c wrote
Do you have any evidence that vaccines cause autism other than that "doctor" that wrote a paper so badly that he lost his medical license?
marrymemercedes t1_ivsu6gj wrote
It is important to note that almost any phase 1 has nothing to do with efficacy and is merely that the drug is safe in healthy subjects. This is still very important and big news in this case as the antibiotic class isnāt new and has been shown to be effective in other configurations, itās toxicity has been what has prevented itās use in the past.
stewartm0205 t1_ivtrhfh wrote
If R&D for antibiotics isn't profitable then it won't get done. This is where the government should step in and fund it.
Guruprakash808 t1_ivs87kr wrote
Thank you. It was very useful.
Can you tell me what is the difference between study period and intake period, for a particular disease area?
FuturologyBot t1_ivsa999 wrote
The following submission statement was provided by /u/tonymmorley:
It might feel at first glance like this is superficial news; (pharmaceutical companies doing capitalist pharmaceutical things), but it's a big deal. Every new and promising antibiotic candidate is a big deal worth celebrating. š
>New antibiotic passes through the first phase of clinical trials with ease
The last truly novel antibiotic compounds that made it to the market were discovered in the 1980s, leaving a void of innovation that has lasted decades, with many experts worried about the very real possibility of an āantibiotic apocalypseā. ā¬ ļø Watch this:
>"The drug, called QPX9003, is a promising candidate for tackling Gram-negative bacteria which cause serious infections like pneumonia, urinary tract infections, peritonitis and meningitis." "Gram-negative āsuperbugsā are becoming increasingly hard to treat, as they develop resistance to most common antibiotics."
Hey team, I'm a progress studies researcher and progress proponent; if you enjoy my content, you're welcome to follow the majority of my work on the blue bird platform (before Elon tanks the platform)
Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/yr6epv/new_antibiotic_passes_through_the_first_phase_of/ivs85w5/
Cam599 t1_ivt43a0 wrote
Seems pretty exciting, just hope it wonāt cost $146 or something ridiculous like that per pill when it comes to market. Big pharma has both parties in its pocket. Have to compare price in Australia vs price here .
Regardless though great news
[deleted] t1_ivtb1xi wrote
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[deleted] t1_ivu3uqt wrote
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OPunkie t1_ivue8h5 wrote
New antibiotics are always great but Iāll wait until itās done with testing and then on the market for a few years before I celebrate.
I sure hope it works out!
WorthMarsupial6101 t1_ivuexpy wrote
Thank goodness my old antibiotic is starting to get all moldy.
Rocketsloth t1_ivux6po wrote
Shit. It's for fighting off Gram-negative bacteria. We really need one the fights off gram-positive bacterial infections like C.Diff.
[deleted] t1_ivvecmf wrote
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Spiced_lettuce t1_ivxg9du wrote
This is massive news, I hope more are to come in the next years
Chr1s78987x t1_iw98es4 wrote
Almost all drugs make it to phase 2 trials so this is hardly shocking. Most drugs fail in phase 3 and almost half fail in phase 2
akanosora t1_ivtkdd8 wrote
Do people realize first phase is not about efficacy at all?
the_uto_aztecan t1_ivtvku4 wrote
Phages. Bacteriophages will be the answer to drug resistant bacteria. Not a new antibiotic.
[deleted] t1_ivthxeq wrote
Yay new drug to help bacteria evolve to be stronger! I canāt wait until viral and fungal antibacterials are readily available.
SkinDrizzle t1_ivtrpeq wrote
Iām not a Scientologist but id try and stay as far away from medication as much as possible you know #depending
A lot of people go to the doctors for basically nothingā bloody tests and a physical should be a yearly occurrence.
hackoslacko t1_ivsb954 wrote
That's good, I'm still overcoming a widespread impetigo infection that resisted the antibiotics, eventually found one that worked but it's scary how resistant bacterial infections are becoming. I shudder at the thought of no antibiotics being able to treat my condition it'd be like dying in slow motion in a gooey yellow fire.