It certainly depends on where you are, how heavy the snow is, if it's currently snowing or snowed recently, etc.

That being said, I tend to try to stick to highways in the snow in rural SW Pennsylvania. I was driving two hours home from taking my son somewhere a few weeks ago. Waze sent me on back roads, but it started to snow. The roads were windy, hilly, narrow, and covered in snow. It was quite stressful. As soon as I had a chance to jump on the turnpike, I did. And it was MUCH safer.