nickoskal024 OP t1_j8nwukl wrote
Reply to comment by TrenchantPergola in Recently a gene therapy for a rare inherited neurodegenerative disorder was approved. How come cure is achieved through bone marrow transplantation? by nickoskal024
Oh yes thanks! I seem to have missed the bit about leukocytes being affected.
It is quite interesting that although the brain is an immune privileged site, that any resident immune cells must come from the bone marrow lymphoid lineage and presumably it is those which are tasked with clearing up the sulfatides. The black box has been resolved :)
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