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cloudwalker0909 t1_irbldt0 wrote

Histamine in the brain is an excitatory neurotransmitter (it has inhibitory effects on certain neurons but is overall excitatory) and is generally wakefulness promoting. Antihistamines that cross the blood brain barrier in sufficient quantities cause sedation through the antagonism of histamine receptors in the brain.

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isblueacolor t1_irchxay wrote

Notably, there is a new narcolepsy medication called Wakix that works by acting on histamine receptors in the brain to increase wakefulness.

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