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When a radioactive substance is touched or consumed, the radioactive particles release energy in the form of ionizing radiation. This radiation can damage or kill cells in the body, leading to various health effects depending on the amount and duration of exposure.

At the cellular level, ionizing radiation can damage DNA and other cellular structures, leading to mutations and cell death. This can increase the risk of cancer and other diseases. The brain and nervous system can also be affected by ionizing radiation, leading to cognitive impairment and other neurological effects.

Our body does not naturally build a defense mechanism against ionizing radiation.

Histirically, there wasn't much selection pressure via high doses of ionizing radiation. Wich in itself explains why our bodies habe no specific response to it.

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I mean how Marie Curie's body responded to it, what information did the cells delivered to brain and how brain perceived it in such a case where it is strange energies penetrating thru and rapid mutating. she lived a lot of years in a radioactive environment and matter of fact is before it was discovered how bad it can be for exposure I am sure she and her team had enough.

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Our body does not have a defense mechanism against ionizing radiation, that is true. Though, we do have countermeasures against its effects.

DDR, or DNA-damage-response, is a cluster of measures cells regularly deploy to restore DNA damage caused by radiation, amongst others. They are not without failure, which is why cancer exists. Nevertheless, these processes are exceedingly powerful when it comes to restoring defective DNA. Without them, cancer would be more frequent by several orders of magnitude.