I work for Pfizer’s oncology R&D group and they’re pretty good at only spending money to develop the most promising drugs and killing off projects early that won’t likely produce a viable drug (like 90% of projects)
Can be anytime really and there’s lots of “go/no-go” checks along the way but the vast majority get killed off before human clinical trials. That is one of the largest costs for drug R&D
Yeah, I remember seeing stat a few years back that for every drug that makes it to market, close to 19 are cancelled before that point. Partially why completed drugs are priced so high before the patent runs out
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