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kjpmi t1_ix3nsq5 wrote

Reply to comment by limiter303 in Customs seize so much cocaine in Belgium that incinerators can no longer keep up by ILikeTasks

MDMA is probably not neurotoxic at recreational doses. That was a myth perpetuated for a long time.
There’s evidence that MDA, though, is probably slightly neurotoxic. MDA is more of a psychedelic high and can be rougher on you and the come down is definitely worse than MDMA.

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limiter303 t1_ix3s038 wrote

I would be interested to see studies that prove that MDMA is not neurotoxic.

Regardless, frequent users are eventually going to experience chronic depression and cognitive issues.

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kjpmi t1_ix3st1a wrote

Well, my understanding is that the data is not conclusive. Some evidence was found in rat studies but that doesn’t always translate to humans.
Here is a retracted study that tried to claim dopamine neurotoxicity from just one dose of MDMA in primates. It turns out they accidentally gave them methamphetamine instead of MDMA. retracted study

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