Submitted by giuliomagnifico t3_10rxlco in science
I was curious how animals such as rats, dogs, monkeys etc might be given heart attacks, and found the following, which may be of interest to others who are similarly curious.
"Myocardial infarctions (MIs) in rats were originally induced by the sequential administration of subcutaneous isoproterenol causing diffuse myocardial necrosis. Subsequent investigators used an electrocautery technique applied to the epicardial surface to induce small, focal infarctions. Soon thereafter, Pfeffer et al developed the rat coronary ligation model that became perhaps the most widely used heart failure and MI model in the decades to follow."
Apparently transgenic animals can also be used, bred to carry mutated genes so that they develop hypertension, hypertrophy and subsequent heart failure.
[removed]
People in the future will look at us as barbarians for what we do to animals, and maybe we are, but it’s true to that without these methods, we may never gain this knowledge.
Interesting. Amazing. Fucked. Damned useful.
Nothing says legit like getting published in Nature.
That's actually an accompanying research highlight. This is the research article: M. T. Spang, et al., Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues, Nature Biomedical Engineering (2022)
people in the future will look at us as barbarians for our current methods of treatment.
Cool now use it for inflammatory bowel disease
[removed]
People always look back at those who live before with disdain.
Are you saying that because you're interested in the microbiome of the gut or because you currently have gut issues?
that was my initial thought when I read the title. what do you think the chances are? timeline would be years if they're 2 years from human trails on the cardio usage no?
[removed]
What of the side effects?
They’re gonna be pissed at the savages that destroyed their planet for aeons.
"You do not settle whether an argument is justified by merely showing that it is of some use. The distinction is not between useful and useless experiments but between barbarous and civilized behaviour. Vivisection is a social evil because if it advances human knowledge, it does so at the expense of human character."
Hmmmmmm.... Enlarged prostate? It only happens to 90% of men eventually.
I'll volunteer for the sciatica trials.
AutoModerator t1_j6y6tkq wrote
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are allowed as responses to this comment. Any anecdotal comments elsewhere in the discussion will be removed and our normal comment rules apply to all other comments.
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.