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AnnexBlaster t1_j7wmgtr wrote

Reply to comment by Hapgam in According to a study on 12,211 patients, aspirin is just as effective at preventing blood clots as low molecular weight heparin, but it costs less and is easier to administer by giuliomagnifico

Yes I do research on the effects of anticoagulant drugs for sepsis, but I haven’t investigated aspirin yet, I suspect though that the toxins in sepsis cause far too much platelet activation for aspirin to handle, ticagrelor on the other hand looks very promising for increasing platelet killing efficiency and host survival.

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memetunis t1_j7x7838 wrote

I go to a clinic to have my port flushed, which is done with heparin. Each room has a sign stating they don't store large amounts of heparin on site, similar to what you see with opioids. Do you know why this would be? I have asked the nurses but they weren't aware.

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BuggerMyElbow t1_j7y68tl wrote

What are the toxins involved in sepsis and where do they come from?

I'd imagine they come from the bacteria, so lipopolysaccharides/endotoxin? Are these responsible for platelet malfunction?

Also how does sepsis vary depending on the species and strain of bacteria?

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AnnexBlaster t1_j7yevf3 wrote

Theres proteins in Staph aureus called clumping factors which active platelets, and pore forming exotoxins called alpha hemolysins which cause major damage.

Sepeis varies a great deal between bacteria, the toxins from different pathogens determine whether your immune system will win, or how fast and painful your death will be

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Balthasar_Loscha t1_j8syjub wrote

Aspirin as a preventative for COVID-related clotting in a male? Not your area, but maybe you heard something?

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AnnexBlaster t1_j8t1s90 wrote

Yes theres studies about this, I think its better than not taking a preventative drug. I want to see a paper about it preventing long covid

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