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luisvel t1_jc8cd3i wrote

Reply to comment by Fixing_The_World in Cancer researchers show introducing bacteria to a tumour’s microenvironment creates a state of acute inflammation that triggers the immune system’s primary responder cells to attack rather than protect a tumour. by unswsydney

And why not inject a mix of bacterial lysates? Seems like a safer cost effective solution.

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cygnoids t1_jc8nhb5 wrote

My assumption is you need to balance stimulating the immune system and causing a severe infection. I need to read the paper to see if it was full bacterial lysate or if you could take some PAMPs to stimulate an immune response

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Fixing_The_World t1_jc9i1in wrote

I suspect you could.

However, while a lysate is different, co-infections don't always have an additive effect when it comes to the immune system. One infection can actually dampen another. It could be quite different with inactive antigens though.

Injecting that many different antigens could also cause immune system derangement ending in autoimmunity &/or cancer escape.

Lastly, from a data collection stand point, trying to figure out which lysate/antigen causes high adverse reactions in a mix would be much harder than collecting data on individual types.

This would all have to be tested of course to gain any knowledge on the manner; it is just what came across my head.

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