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SLKNLA t1_jdlqlgm wrote

Reply to comment by Sir_Vexer in Opposing retrograde and astrocyte-dependent endocannabinoid signaling mechanisms regulate lateral habenula synaptic transmission by dragononawagon

If I’m reading this right, it looks like they’re saying cannabis can make you anxious/depressed by suppressing glutamate and GABA production in your brain.

Edit: I was not reading it right.

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dragononawagon OP t1_jdohrrf wrote

Not quite! Cannabinoids generally suppress neurotransmitter release, but they found some unexpected opposite effects in this brain area, which has been implicated in depression. Happy to discuss specific questions!

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