> ⇒ This study demonstrates an association between atopic disease and the development of OA; patients may benefit from the use of treatments that inhibit mast cells and allergic cytokines to treat or prevent OA.

Ketotifen fumarate (Zaditen®; Swedish Orphan Biovitrum) functions as a mast cell stabiliser and has been used as a treatment for chronic idiopathic urticaria because of its antipruritic properties. Similarly, epinastine hydrochloride is both an antihistamine and a mast cell stabiliser.

Within the flavone class, the most active mast cell stabilizers are luteolin, disometin and apigenin. Using anti-IgE to elicit degranulation, luteolin inhibited the release of histamine, LTs, PG2 and GM-CSF from human cultured mast cells (HCMCs) in a concentration-dependent manner (1–100 μM) (Kimata et al., 2000b). Luteolin also suppressed the production of proinflammatory cytokines TNF-α and IL-6 in bone marrow-derived cultured murine mast cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764846/

Glucosamine stabilizes mast cells as well.

https://pubmed.ncbi.nlm.nih.gov/20093129/