DooDooSlinger t1_iufiiay wrote on October 30, 2022 at 10:51 PM

Reply to comment by SnooPuppers1978 in Study finds Omicron variants of the SARS-CoV-2 virus which appeared at the end of 2021 have marked genetic differences from the ancestral SARS-CoV-2. The many, distinct mutations in their infection machinery have enabled them to escape from antibodies elicited from the original series of vaccines. by MyLifeisAsaJoker

There is entirely too much focus on humoral immunity in talk about vaccines. It is clear that antigenic drift in SARS cov 2 is extremely rapid and that antibodies are (thankfully) short lived. We will not generate lasting neutralising antibodies with vaccines. But that doesn't matter, the cellular response is extremely strong and much less sensitive to mutations in binding epitopes. For older or immunocompromised people, where t cd8 response is impaired, boosters or long lasting IG are probably the only option for continued protection.