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CognitiveFunction34 OP t1_ismjcnh wrote

>A cross-linkage analysis of more than 90,000 deliveries has found that women with a history of PCOS were at a higher risk of gestational diabetes, pre-eclampsia and Caesarean section than those without PCOS; extra monitoring is advised for PCOS pregnancies.
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>A prodigious cross-linkage registry study from the USA has confirmed what many smaller studies have previously found, that pregnant women with polycystic ovary syndrome are at increased risk of gestational diabetes, hypertensive disorders of pregnancy and delivery by Caesarean section.(1) Moreover, the infants born to PCOS women were found at increased risk of low birthweight, small for gestational age, preterm birth, prolonged neonatal hospital stay and infectious and respiratory conditions within the first year of life.
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>The risks of such pregnancy complications were found sufficiently high for the authors to advise that ‘obstetricians should be aware of patients’ PCOS status and closely monitor for potential pregnancy complications to improve maternal and infant perinatal health outcomes’. Adjusted relative risks for gestational diabetes were 1.51 (1.38-1.65), for pregnancy induced hypertension 1.25 (1.15-1.35) and Cesarean section 1.07 (1.02-1.11). The association between PCOS and gestational diabetes was strongest in women with a pre-pregnancy BMI of <30 kg/m2. The authors’ warning echoes that of the 2018 international guidelines on PCOS, which similarly recommended increased monitoring for women with PCOS during pregnancy.(2)

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Most-Performer-5064 t1_isogvi4 wrote

Women with pcos are more inclined to be overweight. Excess weight in itself causes the same problems. They should make the follow up study about outcome of pregnancy in obese women with pcos and without pcos.

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Thin_Insect_3005 t1_isq7vp3 wrote

But the association was stronger in women with a lower BMI

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Most-Performer-5064 t1_isrcrtn wrote

Bmi of lower than 30kg/m2. This can mean whatever I want to believe. The thing with pollicystic ovarian syndrome is that you have to be obese to have pcos. The other part of the spectrum are the women who have a bmi of <20kg/m2 and pollicystic ovaries without insulin resistance. 165 cm, 50kg is a Bmi of 18,4 165 cm, 80kg is a Bmi of 29,4 I would say that second woman would have a greater chance of having insulin resistance than the first.

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Thin_Insect_3005 t1_isrvps1 wrote

Still, the trend should be the other way around, how can pcos women with bmi>30 have less insulin resistance than bmi<30 ? Everybody agrees about the common sense parts you mention, of course a fat person would have more metabolic disorders. But the hormonal mechanisms behind gestational diabetes are yet to be clarified and do not only depend on the usual T2 diabetes stuff.

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Most-Performer-5064 t1_isrzbo1 wrote

Weight was not specify, that was my problem.

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Thin_Insect_3005 t1_isuv61k wrote

The interest of BMI is it's more informative than weight

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Most-Performer-5064 t1_isw76ci wrote

Weight or bmi dosent matter when a woman is overweight or obese. Excess adipos cells elevate inflamatory markers in the body. Is it worse with a person who has pcos or not? If it is worse with pco than follow up study should be about weight and pco.

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