SpaceObama t1_iuu0bru wrote on November 3, 2022 at 12:24 AM

Reply to comment by oldastheriver in Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression | NEJM by 9mac

I wish this study differentiated between suicidal ideation and suicidal behaviours during the trip.

From my own experience, mindset and physical setting are hugely influential to a trip. I wonder what the setting was like. Alone in a university hospital clinic on psychedelics sounds horrifying. Alone in general is a bit intense. Ideally you need a good trusted friend, but I don’t know how to replicate that in a clinical setting.

oldastheriver t1_iuu255j wrote on November 3, 2022 at 12:37 AM

I had an interesting conversation with someone who was sexually molested by their father at the age of seven, basically they have suicidal ideation every day, and they are on prescription medication, the the best most effective whatever works. Yeah it's a big problem in this study. It's what I call jumping to conclusions

SaltZookeepergame691 t1_iuvrynt wrote on November 3, 2022 at 11:45 AM

Rates of suicidal ideation were low and similar between all groups. The only events of “severe” suicidal ideation were balanced across groups and happened after day 1. Data is in table 3.

PickledPixels t1_iuv16by wrote on November 3, 2022 at 5:36 AM

Anecdotally, I've eaten mushrooms dozens of times and I don't think I've ever had a suicidal ideation. I don't know what kind of atmosphere you would have to be in for that..

oldastheriver t1_iuyielw wrote on November 3, 2022 at 11:24 PM

I mean I would like to think that people that are suicidal every day, hence they have major depressive disorder, I would like to think that you know eating a mushroom would give them one day without those feelings. But it's more likely that it just opens a window, it may not even be an entire day, without depression.

TwoHundredPlants t1_iuvym9v wrote on November 3, 2022 at 12:46 PM

I haven't read this exact paper, but most psychedelic researchers have created a standard treatment protocol, usually two other adults in the room (a therapist/guide and/or researcher), and a calm environment (couches, blankets, low light, soothing music, headphones, plants, etc). I've read zero current research where someone is left alone or is in a standard bright clinic space.