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1

Grunslik t1_j2uu0xu wrote

Ah, another "this works exactly as expected" study. So drugs designed to hinder the body's immune system lowered patients' immunities? I'll notify the Nobel committee immediately!

I know these studies have to be done to establish the science, but they're still a bit funny to me. :)

289

EvokeNZ t1_j2v4mr1 wrote

I thought this was known from the start. In NZ anyone who is immunocompromised is eligible for three primary doses and two boosters. Also advice was given to skip immunosuppressants during the vaccine week.

37

discgman t1_j2v8csi wrote

Yes we in RA community already are aware of this. Is why we stop meds when we get vaccinated

38

braellyra t1_j2v9g8q wrote

Replying to discgman (#1,276,101)

I was told not to stop my meds, since I flare really easily and I’ve already failed 2 DMARDs (infections and frequent stopping due to the infections which then made them less effective against the flares) ugh. RA is just the gift that keeps on giving.

27

aSharkNamedHummus t1_j2vclmi wrote

Replying to [deleted] (#1,275,270)

Cool that you can control your symptoms with diet. Some of us can’t. Granted, I’ve never taken immunosuppressants to manage my IBD, but I fully understand the people who do. Chronic, never-ending flares can wreck your physical health and will wreck your mental health.

7

Dapper-Goat4408 t1_j2vj2qz wrote

Anyone have the vaccine exacerbate their autoimmune disease? Mine was so bad I have basically a “no more mRNA shots” on my medical records.

16

Arvis1983 t1_j2vlbux wrote

I take immunosuppressants for an organ transplant

My docs concern was I wouldn’t develop immunity as well, but I got super sick from the 1st I took.

I’ve had my boosters, and fortunately have not contracted COVID. Im careful about crowds, and work from home, but I don’t mask anymore

I do thinks there’s validity to this, but it’s case-by-case as well

14

Person012345 t1_j2vqkdi wrote

So immuno-suppressants supress the immune system. Got it.

23

Mountainstreams t1_j2w2o22 wrote

Replying to Dapper-Goat4408 (#1,276,847)

The risks of POTS after Covid-19 vaccination & SARS cov2 infection POTS isn’t a typical autoimmune in how it’s treated but it’s triggered by shocks to the immune system. My wife developed it along with a few other autoimmune issues after her 2nd Covid vaccine. I’d imagine Covid could also be a trigger for new autoimmune conditions too. Here’s another paper that lists a few autoimmune diseases including RA. New-onset autoimmune phenomena post-COVID-19 vaccination

5

RuinedBooch t1_j2wegtk wrote

Immuno-suppressants suppress the immune system, you say? Preposterous!

7

smokinsuzy2000 t1_j2wl0b8 wrote

Replying to braellyra (#1,276,155)

I'm on immunotherapy for RA and Regeneron reached out to me to say not to take any vaccines. So I said, right I shouldn't take live vaccines. Their reply? No vaccines. I couldn't believe that coming straight from big pharma.

5

startrekgeek1966 t1_j2wofit wrote

I think people are reaching for a simple dissertation subject with the best intentions but don’t think it through to its logical conclusion.

3

Mumblerumble t1_j2wqpij wrote

On humira. Very aware of how it’s likely to blunt the effectiveness of immunizations. I was extremely careful when the pandemic was particularly intense and I’m back to being a hermit again. Oh, well.

9

braellyra t1_j2x2ncn wrote

Replying to smokinsuzy2000 (#1,278,152)

Woah, that’s a bit ridiculous. My rheumatologist—and every rheumatologist I’ve spoken with since getting diagnosed almost 10 years ago—has said the more non-live vaccines the better, and I should get vaccinated against as many things as I possibly can. Maybe it varies by the specific action of certain RA meds? (DMARDs vs TNF blockers vs etc)

10

czerniana t1_j2xfdwc wrote

I’ve got MS and am on immunosuppressants. We on them are also aware of this. It just makes sense. I appreciate that we needed to know by how much the difference would be, but still…. Not surprising. Reminds me I need that last updated booster. Maybe I’ll schedule that soon.

5

GnomieOk4136 t1_j2xq35x wrote

Replying to braellyra (#1,276,155)

I was told not to stop the first time, and I ended up having reduced response. The second time I did stop, and I got the jou of a flare and a full blown Covid shot response at the same time. Most miserable month in my memory! My doctors were VERY clear though that I had to have the vaccines and needed to be extraordinarily careful even after I got them. RA with biologics makes our risks so much higher. Worst gift ever!

3

GETitOFFmeNOW t1_j2y40ea wrote

Replying to Grunslik (#1,275,327)

It's interesting to note that the drug that was pushed by Trump, hydroxychloriquine (Plaquenil) is used as an immunomodulator for lupus and Sjogren's patients (though, it's usefulness in that regard is being questioned.)

2

e-rinc t1_j2ybszn wrote

I’m on pretty close to max dose per kg of inflectra and thankfully have been able to avoid covid so far. Double boosted and mindful, but also just lucky I’m sure. Those first few months were scary af - before we really knew anything about how it traveled and things.

1

Peteostro t1_j2yrj77 wrote

Replying to discgman (#1,276,101)

The question (not sure if this study answers) is if you go off immune suppressant, get the vaccine and then go back on a month or so later does it reduce your chance of fighting off Covid. I would assume the answer would be yes? My doc wants me to go back on my medication (stopped it in 2020 for Covid) and said they haven’t seen any more increased Covid severity with their patients on immune suppressant medications. Not sure if this is just them being optimistic. This study seems to contradict what they told me.

3

funchefchick t1_j2ysjm8 wrote

Not all immunosuppressants are equal, is the thing. The one I take (Enbrel) did NOT suppress COVID vaccine immune response - not one bit.

Some months after my first 2 Moderna doses I was having some blood work done, so we added a COVID antibody test to the list. I've never had COVID. (knock wood).

1.0 units per milliliter (U/mL) or higher indicates the presence of SARS-CoV-2 antibodies. Anything less means no antibodies detected.

Mine was 212.

When I pressed my rheumatologist later to get a dose of EvuSheld for safety . .. they explained that since my immune system is responding to the vaccine doses and building antibodies - despite me taking immunosuppressants weekly - I don't need EvuSheld as much as people who are NOT responding to vaccines.

So yeah. Your immunosuppressant mileage may vary.

https://creakyjoints.org/living-with-arthritis/coronavirus/covid-19-vaccines/immunosuppressant-medication-response-to-covid-19-vaccine-study/

2