Yes and no. Yes, the explosion would keep expanding and any particles in said expansion would keep going out in a sphere until they interacted with something else with mass. However, it would not continue to be a "sphere of death" because as it continued to expand, the particles would be spread over larger and larger distances in a sphere around the original point of explosion. The energy imparted on the particles would dissipate through radiation but the particles themselves would get further and further apart.

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It's still just hot particles that would cool and disperse over time and distance

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I think a good portion of the force is produced by super heated air expanding. Without air it would just be a release of energy that has nothing to push.

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