I take the principal that Humans, although unique in detail, are more or less typical for what we should expect for the type of life that develops ET. I say this not that we are special or super stars, but that we are probably more normal and and typical rather than some sort of extreme edge case.

The whole us using oxygen thing is probably nothing special and if we ever get our hands on Encyclopedia Galactica and get to browse the countless known sentient species that consuming oxygen will be more or less the norm.

We can have two takes. Oxygen is something that makes us special, it is our unique, or at least very, thing in the galaxy that makes life on Earth very special, and very rare. Something that makes humans special is our ability to breath oxygen.

And then the other take. Oxygen consuming animals are super common, most life that isn't microscopic consumes Oxygen. The Great Oxidation Event is probably a fairly typical thing to happen early in a planet's history. We are not special because we consume oxygen.