The Sopranos? The story of a group of macho men with macho voices who are surprised to discover that when they sing, for some mysterious reason, they're sopranos!

The King of Queens? A member of a group of drag queens discovers they're actually the long lost son of a king who just died, and they're first in line for the throne!

All in the Family? A family changes their detergent to All, and suddenly everyone develops special powers. It's a web series created by the makers of All detergent.

Laverne and Shirley? The plot wouldn't change, it would just be the Shirley-less last season of Laverne and Shirley.