I've lived in DC for 37 years and have been a fed through Obama, Trump, and now Biden. I noticed basically zero difference in the "culture of DC" between administrations.

That being said, there are definitely city-wide mood swings. The weeks and months after the elections of Obama and Trump were definitely palpable in their jubilation and sorrow. The months after January 6th were noticeable in their shock and disgust. I don't think any of those things changed the overall culture of DC though.

Each new administration only gets about 4,000 appointees, only 1,600 of which require Senate confirmation. (i.e. are anyone actually important.) Many, probably most of them will choose to live in the rich MD/VA suburbs. There just aren't enough people to make a big difference.

Also, you're probably asking the wrong people. Except for maybe the upper crust of Georgetown and Kalorama who actually do hobnob with appointees at their clubs, us regular joes aren't connected with that world. You know where the biggest concentration of DC natives is? Wards 7 and 8. Nobody over here is getting invited to parties with Janet Yellen or Antony Blinken.