Ezekiel_W
Ezekiel_W OP t1_isd75wu wrote
Reply to comment by [deleted] in ‘Near-limitless CRISPR therapies’: This drug delivery breakthrough helps gene editing technology infiltrate cells by Ezekiel_W
CRISPR wast invented in 2012.
Ezekiel_W OP t1_isaxjev wrote
Reply to ‘Near-limitless CRISPR therapies’: This drug delivery breakthrough helps gene editing technology infiltrate cells by Ezekiel_W
>Using chemical design and synthesis, the team brought together the Nobel-prize winning technology with therapeutic technology born in their own lab to overcome a critical limitation of CRISPR. Specifically, the groundbreaking work provides a system to deliver the cargo required for generating the gene editing machine known as CRISPR-Cas9. The team developed a way to transform the Cas-9 protein into a spherical nucleic acid (SNA) and load it with critical components as required to access a broad range of tissue and cell types, as well as the intracellular compartments required for gene editing.
Ezekiel_W OP t1_isaxg6z wrote
Reply to ‘Near-limitless CRISPR therapies’: This drug delivery breakthrough helps gene editing technology infiltrate cells by Ezekiel_W
>Using chemical design and synthesis, the team brought together the Nobel-prize winning technology with therapeutic technology born in their own lab to overcome a critical limitation of CRISPR. Specifically, the groundbreaking work provides a system to deliver the cargo required for generating the gene editing machine known as CRISPR-Cas9. The team developed a way to transform the Cas-9 protein into a spherical nucleic acid (SNA) and load it with critical components as required to access a broad range of tissue and cell types, as well as the intracellular compartments required for gene editing.
Ezekiel_W OP t1_isavnsi wrote
>Moderna Inc., the company that shot to fame after developing the vaccine for COVID-19, has teamed up with the pharmaceutical giant, Merck, to develop a personalized vaccine against skin cancer, CNBC reported. If successful, the vaccine will be used in high-risk patients of melanoma, the deadliest known skin cancer.
Ezekiel_W OP t1_is2p4vs wrote
Reply to comment by Tavrin in AIs are now expert-human-level in no-press Diplomacy and Hanabi by Ezekiel_W
Oh, that is neat. Though this is a little bit different and of much greater importance than that cooperation.
Ezekiel_W OP t1_is1vibz wrote
Reply to comment by Akimbo333 in Battery tech breakthrough paves way for mass adoption of affordable electric car by Ezekiel_W
>Depending on the source of power charging an EV, it could take days or mere minutes to significantly charge a battery. EV charging stations are typically categorized as either level 2 or level 3; however, even an outlet at home will charge your EV (albeit rather slowly). You can expect a home outlet (sometimes called a level 1 charger) to take around 40 hours to fully charge a typical EV.
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>Level 2 chargers decrease time significantly: Most can deliver about 15-25 miles of range per hour, meaning that most EVs can be charged either overnight or during a typical work day. These are a great option to have at work or home.
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>Level 3 is where speed is really ramped up, and there is a wide range of power output for level 3 chargers. These chargers utilize direct current (DC) power and cost a lot more money than other charging stations, so they are typically implemented in public charging infrastructure. Some level 3 chargers can top up an empty battery in as little as 30 minutes. Many are already designed to output much more power than current EV batteries can receive, so the future looks bright for extremely short charging times.
Ezekiel_W OP t1_is1v3gj wrote
Reply to comment by lifebeyondwalls in AIs are now expert-human-level in no-press Diplomacy and Hanabi by Ezekiel_W
Correct, DOTA bots played against humans, not with them as far as I know. This shows that AI can now play cooperative games along with and against human players at expert levels.
Ezekiel_W OP t1_is1umsb wrote
Reply to comment by Scope_Dog in Researchers Develop a CRISPR-Based Therapy That Penetrates Solid Tumors by Ezekiel_W
We are still learning a lot and improving things with CRISPR and mRNA tech, the real magic happens a little later this decade.
Ezekiel_W OP t1_is1fusw wrote
Very cool and very interesting. I highly recommend people take a look at this thread.
Ezekiel_W OP t1_is1bz2n wrote
Reply to Battery tech breakthrough paves way for mass adoption of affordable electric car by Ezekiel_W
>A breakthrough in electric vehicle battery design has enabled a 10-minute charge time for a typical EV battery. The record-breaking combination of a shorter charge time and more energy acquired for longer travel range was announced today (Oct. 12) in the journal Nature.
Ezekiel_W OP t1_irzbnna wrote
Reply to comment by Snortykins in Researchers Develop a CRISPR-Based Therapy That Penetrates Solid Tumors by Ezekiel_W
Then the answer is yes, it has.
Ezekiel_W OP t1_irz9ioa wrote
Reply to comment by Snortykins in Researchers Develop a CRISPR-Based Therapy That Penetrates Solid Tumors by Ezekiel_W
That would depend on what you mean.
Ezekiel_W OP t1_irxtiqr wrote
Reply to comment by gibecrake in Researchers Develop a CRISPR-Based Therapy That Penetrates Solid Tumors by Ezekiel_W
CRISPR is continually making breakthroughs, posting all of them would mean posting almost every day with updates, which I am too lazy for.
Ezekiel_W OP t1_irxairn wrote
>In a paper recently published in Nature Nanotechnology, Siegwart and his team developed a dual approach using LNPs equipped with tools that allow them to access and modify the tumor.4 The researchers packaged the LNPs with a CRISPR-Cas9 system that genetically modified and disrupted PD-L1 gene expression. PD-L1 overexpression inhibits T cell infiltration within the tumor microenvironment, so deactivating the gene allows immune cells to access the tumor. To grant the CRISPR system and immune cells tumor access, the LNP also included siRNA that targeted and reduced the expression of focal adhesion kinase (FAK), which diminished the density of the extracellular matrix surrounding the tumor.
Ezekiel_W OP t1_irxa6nl wrote
>By packaging lipid nanoparticles with elements that decrease the fibrous nature of solid tumors, researchers can deliver CRISPR therapies in a more efficient manner.
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>In a paper recently published in Nature Nanotechnology, Siegwart and his team developed a dual approach using LNPs equipped with tools that allow them to access and modify the tumor.4 The researchers packaged the LNPs with a CRISPR-Cas9 system that genetically modified and disrupted PD-L1 gene expression. PD-L1 overexpression inhibits T cell infiltration within the tumor microenvironment, so deactivating the gene allows immune cells to access the tumor. To grant the CRISPR system and immune cells tumor access, the LNP also included siRNA that targeted and reduced the expression of focal adhesion kinase (FAK), which diminished the density of the extracellular matrix surrounding the tumor.
This is really good news. One of the biggest challenges with mRNA and CRISPR therapies for cancer treatments is penetrating solid tumors.
Ezekiel_W t1_iruldlo wrote
Reply to comment by fuckdonaldtrump7 in what jobs will we have post singularity? by theferalturtle
I am only talking about modern industrialised countries.
Ezekiel_W t1_irtqsxz wrote
Reply to comment by AdorableBackground83 in what jobs will we have post singularity? by theferalturtle
You won't have to wait 100 years, more like 10-25.
Ezekiel_W OP t1_irt34ut wrote
Reply to comment by esoteric23 in AI art 256x faster by Ezekiel_W
This is the reason Nvidia has put 4x the number of AI cores in their newest GPUs, they believe as I do that all games in the near future will be simulations created with AI.
Ezekiel_W OP t1_irrrk6e wrote
Reply to AI art 256x faster by Ezekiel_W
>On ImageNet 64x64 and CIFAR-10, our approach is able to generate images visually comparable to that of the original model using as few as 4 sampling steps, achieving FID/IS scores comparable to that of the original model while being up to 256 times faster to sample from.
Soon diffusion models will run on smartwatches.
Ezekiel_W t1_irjflki wrote
Reply to Singularity, Protests and Authoritarianism by Lawjarp2
Historically speaking protests don't really do much, violence in one way or another has always been a necessity.
Ezekiel_W t1_irg9mq9 wrote
Very impressive.
Ezekiel_W t1_irfk1fu wrote
Reply to comment by FilthyCommieAccount in “We present 3DiM (pronounced "three-dim"), a diffusion model for 3D novel view synthesis from as few as a single image” by Shelfrock77
You will speak software into existence within 3 years.
Ezekiel_W t1_ircxdec wrote
Reply to comment by dreamedio in We are in the midst of the biggest technological revolution in history and people have no idea by DriftingKing
I am honestly surprised anyone who does research into this subject would think otherwise. I am always open to hearing other's ideas on the subject though.
Ezekiel_W OP t1_isd7i7p wrote
Reply to comment by MrDreamster in ‘Near-limitless CRISPR therapies’: This drug delivery breakthrough helps gene editing technology infiltrate cells by Ezekiel_W
We need those 10 or so years for more research and development. Humans have had CRISPR used on them many times already, but it's still early days for human trials. Most of the good stuff with CRISPR probably won't start appearing until the late 2020s.