this isn't a complete answer but some of it will be mode of delivery. Injected > ingested > inhaled(sometimes depends on how your cytokine storm goes) > skin.
I had severe anaphylaxis after injected immunotherapy gone wrong, and that was for a grass allergy. I had critical asthma but not anaphylaxis like that to grass. The difference was mode of delivery.
Comparatively most pollen/hayfever will be inhaled, with the coating of the sinuses catching most of the allergens, compared to ingested with there not being the sinus mucus protection, but there still being some limited esophageal mucus, and stomach pH as protection, and that compared to injected(IE bee stimgs) having very little primary protection at all since it is into skin and/or muscle/blood by capillary, being the most direct action.
JazzyWarrior t1_iuv0w4e wrote
Reply to Why do some allergens (e.g. certain pollens) cause mild allergic reactions, but others (e.g. nuts, bee venom) cause life-threatening reactions? by com2420
this isn't a complete answer but some of it will be mode of delivery. Injected > ingested > inhaled(sometimes depends on how your cytokine storm goes) > skin.
I had severe anaphylaxis after injected immunotherapy gone wrong, and that was for a grass allergy. I had critical asthma but not anaphylaxis like that to grass. The difference was mode of delivery.
Comparatively most pollen/hayfever will be inhaled, with the coating of the sinuses catching most of the allergens, compared to ingested with there not being the sinus mucus protection, but there still being some limited esophageal mucus, and stomach pH as protection, and that compared to injected(IE bee stimgs) having very little primary protection at all since it is into skin and/or muscle/blood by capillary, being the most direct action.