Sariel007

Sariel007 OP t1_ixv5kr0 wrote

Reply to comment by demonmariner in A novel medication for hemophilia B has just been approved by the Food and Drug Administration. The treatment is a form of gene therapy, intended to replace a dysfunctional gene that leaves people unable to control their bleeding. by Sariel007

One dose cure instead of "...patients will undergo regular infusions of their missing clotting factor. Though effective at stopping spontaneous bleeding, these infusions are not a cure and in the most severe cases, people may need to get them every two to three days—a costly and time-consuming measure. "

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Sariel007 OP t1_ixuzrk7 wrote

Reply to comment by GratefulOctopus in A novel medication for hemophilia B has just been approved by the Food and Drug Administration. The treatment is a form of gene therapy, intended to replace a dysfunctional gene that leaves people unable to control their bleeding. by Sariel007

In an analysis of the drug development costs for 98 companies over a decade, the average cost per drug developed and approved by a single-drug company was $350 million.[3] But for companies that approved between eight and 13 drugs over 10 years, the cost per drug went as high as $5.5 billion.

https://en.wikipedia.org/wiki/Cost_of_drug_development#:~:text=In%20an%20analysis%20of%20the,as%20high%20as%20%245.5%20billion.

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Sariel007 OP t1_iwz70uu wrote

Reply to Quantum Microscopes Could Enable Atom-Scale MRI by Sariel007

>A new prototype “quantum microscope” may one day analyze matter with unprecedented detail, researchers say. The novel device may one day probe the performance of next-generation atomically thin 2D electronics, and run MRI scans on molecules to help gain key insights for medical breakthroughs, a new study finds.

>Quantum microscopy uses quantum sensors to map the magnetic, electrical, thermal, and other features of samples at microscopic scales. In the new study, researchers developed a prototype quantum microscope based on flakes of hexagonal boron nitride. This ceramic often finds use as an insulating material in atomically thin 2D electronics.

>The prototype microscopy system places hexagonal boron nitride flakes 10 to 100 nanometers thick on top of samples. These samples possess defects wherein boron atoms are missing. When these negatively charged vacancies are illuminated with a green laser beam, they fluoresce with near-infrared light. Magnetic, electrical, thermal, and other disturbances can alter this response, allowing these defects to help serve as sensors. Each hexagonal boron nitride flake is essentially an array of sensors.

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Sariel007 OP t1_iw7jngc wrote

Reply to COP27: Israel harnessing DNA of bygone wild crops to enhance food supply by Sariel007

>Scientists in Israel are creating a gene bank from the seeds of local wild crops, some that have survived for thousands of years since the birth of agriculture and that may help farmers deal with a harsher climate in the coming decades.

>In a eucalyptus grove nestled between an industrial zone and a new railroad under construction, botanist Alon Singer collected seeds from a number of plants recently spotted, including a variety of water mint, that will be frozen and stored at the Israel Plant Gene Bank at the Volcani Institute, the national agricultural R&D center.

>Singer is combing the country along with other scouts and foragers in search of varieties of wheat, barley and countless other wild crops so their genetic makeup can be saved and studied before they are lost to expanding deserts and urbanization as the climate warms.

>"The plants here are very unique. They are the ancestors of many of the cultivated plants used today," he said.

>Resilient characteristics can be harnessed to genetically modify farmed crops so they better withstand drought or disease.

>Tens of thousands of types of seeds are stored in the gene bank. It may be smaller than some collections elsewhere in the world but the gene pool here is unique, coming from an area that was part of the Fertile Crescent region known as the birthplace of crop cultivation.

>"This is where agriculture started about 10,000 years ago," said Einav Mayzlish-Gati, director of the gene bank. "Species that were domesticated here are still in the wild adapting along the years to the changes in the environment."

>The research has already been paying off. For example, the institute has engineered a variety of wheat with an ultra-short lifecycle. It may not be able to compete today, but it could be a saving grace in a hotter climate with reduced growing seasons.

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