So why are you posting it?

I guess I’ll add the first scientific comment here. Man, r/science rapidly devolving.

Major issue with this study is the lack of adjustment for family factors which may increase the need/desire for screen time to be higher. These are especially important factors when looking at behavioural issues associated with “focus”.

Not all type 1s need long-acting insulin. For example, those on pumps. Because the short acting is delivered throughout the day and night. Theoretically this drug could be designed to fulfill both roles, if they made it glucose sensitive.

Sure. But type two diabetes is progressive and almost all those patients will eventually fail because of the nature of their disease. What will make this drug useful is if it was the only thing required, aka a short acting insulin mimetic, which will actually regulate blood sugar in an impressive way. Most type 2s on long acting are also on other oral antidiabetic medications because long acting just doesn’t really lower blood sugar a whole bunch.

Source: I’m a type 1 diabetic, did my PhD in metabolic disease, and worked in research for a large pharmaceutical company in their diabetes portfolio.

Yeah I worked for a company that was producing one but it didn’t work so the project was shuttered. Hopefully someone can sort it out.

No because insulin is about timing. You take insulin in response to a meal. If you just pop a pill in the morning, there’s nothing to tell the mimetic to begin or stop acting.

The next step will be to make this, or something similar, glucose-sensitive. Unfortunately a molecule that will always be around/active in the blood mimicking insulin isn’t really that useful, as it would cause a crazy amount of hypoglycaemia. Hence why we need something that will only become active/more active in the presence of glucose.

Maybe it’s naive to think this aloud, but I recently got a glimpse of what a small, simplistic view of what the metaverse could be when I recently bought the Quest 2. I played the Rec Room game for about 15 minutes and all I heard was a bunch of kids running around calling each other racial slurs and saying awful things to anyone they crossed. I’m not convinced the adult version is going to be a whole lot better.

One of the really big issues around CBD and it’s ability to reduce seizures is the fact that it’s always taken with other antiseizure medications (ASMs) in studies. Now, on the surface, this isn’t a problem for most ASMs, until you realize that CBD has a very potent effect on CYP enzymes, which many ASMs are metabolized by. As a result, the increased bioavailability of antiseizure medications is seen when CBD is administered. Does this have an impact on seizure outcomes? Are we inappropriately assuming CBD has a direct antiseizure effect? Unfortunately many of these studies can’t address that question.

Interracial thanksgiving. Thank you for being so progressive.

The best part of the story is the quote from the driving school instructor who says “I’m not a fan of sarcasm”. Like you just know that person is fun.

Gotta love what you do

So shouldn’t it have wheels?

I see the pony but where is the bicycle