When you stub your toe on the bed you’re activating mechanoreceptors on nerve endings that tell your brain you’re in pain.
Simple pain medications ( paracetamol, NSAIDs) turn down nerves via reducing inflammatory markers which activate these nerves.
Opioids reduce the firing of nerves so they would reduce the pain felt from banging your toe. It’s why patients are given opioids before surgery so they don’t react to the surgeons scalpel
phreshlord t1_j01eczi wrote
Reply to Why does normal pain medicine helps you with a headache for a few hours but not make you immune to all pain? by popolvar
When you stub your toe on the bed you’re activating mechanoreceptors on nerve endings that tell your brain you’re in pain. Simple pain medications ( paracetamol, NSAIDs) turn down nerves via reducing inflammatory markers which activate these nerves. Opioids reduce the firing of nerves so they would reduce the pain felt from banging your toe. It’s why patients are given opioids before surgery so they don’t react to the surgeons scalpel