punkrockscience
punkrockscience t1_j9vq5l5 wrote
Not much - but in a way, that’s a good thing!
The current vaccine is made for human flu variants. Avian H5N1 is currently pretty different from the circulating human variants that the vaccine targets. While this is why the human vaccine offers little protection against avian H5N1, it’s also why the likelihood of you catching avian H5N1 from a bird is relatively low.
The human flu viral variants have evolved to fit human cellular surface proteins, not bird ones, and the antibodies the vaccine generates are to the human viral variants. The avian flu variants have evolved to fit avian cellular surface proteins, which don’t look a lot like human ones.
As long as the avian virus is only fitting well to avian proteins, it will stay difficult for humans to catch it. Weirdly, if the human vaccine were to start offering us more protection - because the avian virus had evolved to start fitting human proteins better - we’d be in more trouble.
punkrockscience t1_j9vqnku wrote
Reply to comment by somewhat_random in Does the common flu vaccine offer any buffer against H5N1 (Bird Flu)? by Esc_ape_artist
Prediction of what goes into the yearly vaccine is about a year or more out from the flu season it gets administered in. To make the flu vaccine, the flu virus (or viruses, since the seasonal vaccine usually contains multiple strains) has to be cultured in millions of eggs, isolated, purified, combined, and turned into vaccine. It’s a very slow process.
This is one of the reasons that an mRNA vaccine for flu could be such a groundbreaker. The turnaround time is potentially much shorter.